| Function | Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 3Smc Protein 3Smc-3Basement Membrane-Associated Chondroitin ProteoglycanBamacanChondroitin Sulfate Proteoglycan 6Chromosome-Associated PolypeptideHcap |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinBefore Prophase It Is Scattered Along Chromosome ArmsDuring ProphaseMost Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By PlkExcept At CentromeresWhere Cohesin Complexes RemainAt AnaphaseThe Rad21 Subunit Of The Cohesin Complex Is CleavedLeading To The Dissociation Of The Complex From ChromosomesAllowing Chromosome SeparationThe Phosphorylated Form At Ser-1083 Is Preferentially Associated With Unsynapsed Chromosomal Regions |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Protein 3 antibodyAnti-Smc Protein 3 antibodyAnti-Smc-3 antibodyAnti-Basement Membrane-Associated Chondroitin Proteoglycan antibodyAnti-Bamacan antibodyAnti-Chondroitin Sulfate Proteoglycan 6 antibodyAnti-Chromosome-Associated Polypeptide antibodyAnti-Hcap antibodyAnti-SMC3 antibodyAnti-BAM antibodyAnti-BMH antibodyAnti-CSPG6 antibodyAnti-SMC3L1 antibody |
Information sourced from Uniprot.org
