Anti-SMAD4-R361H Mutant antibody (STJA0033671)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the internal region of SMAD4 which includes the mutation of R361H, human origin.
General Information
| Short Description | Mouse monoclonal anti-SMAD4-R361H Mutant for use in WB, IHC-P and ELISA in Vertebrates samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Mouse |
| Reactivity | Vertebrates |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Purified from ascites |
| Dilution Range | WB-1:500-1:1000IHC-P-1:50-1:100ELISA-1:1000-1:2000 |
| Formulation | Liquid in PBS (without Mg2+ and Ca2+) , pH 7.4, 150 mM NaCl, 50% glycerol |
| Storage Instruction | Store at-20°C. Avoid freeze/thaw cycles. |
Target Information
| Immunogen | A synthetic peptide from the internal region of SMAD4 which includes the mutation of R361H, human origin. |
Additional Info
| Background | SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-Beta signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiple colorectal cancers and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominant disease juvenile polyposis syndrome (JPS). |
Information sourced from Uniprot.org