![Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149014/346628/STJ16100296_1__35568.1681998698.jpg?c=1 "Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)")
![Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149014/346628/STJ16100296_1__35568.1681998698.jpg?c=1 "Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)")
Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenBacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
General Information
| Short Description | Mouse monoclonal anti-SLP-76 for use in WB and IHC-P in Pig, Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Mouse |
| Reactivity | Pig/Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SLP-76/03 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag |
Additional Info
| Background | SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation. |
Information sourced from Uniprot.org