Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)

Anti-SLP-76 antibody [SLP-76/03] (STJ16100296)

SKU:
STJ16100296-01
$773.49
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Short Description :Mouse monoclonal anti-SLP-76 for use in WB and IHC-P in Pig, Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IHC-P
Host:Mouse
Reactivity:Pig/Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SLP-76/03
Isotype:IgG2b
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Purified by protein-A affinity chromatography.
Formulation:Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Immunogen:Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Background SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJ16101300 Anti-SLP-76 antibody (STJ16101300) Rabbit Polyclonal Human WB/IHC-P
STJA0040384 Anti-SLP-76 antibody [PT1408R] (STJA0040384) Rabbit Monoclonal Human/Mouse/Rat WB/IHC/IF/ELISA
STJE0020669 Human SHC/SLP-76 (SH2-Containing Protein) Sandwich ELISA Kit (STJE0020669) Human ELISA
STJ70040 Anti-BLNK/SLP-65 antibody (C-Term) (STJ70040) Goat Polyclonal Human/Mouse/Rat/Dog/Pig/Cow Pep-ELISA/WB/IF/FC
STJ22490 Anti-ACP5 antibody (76-325) (STJ22490) Rabbit Polyclonal Human/Mouse/Rat WB/IHC-P/IF/ICC/ELISA

Related Products

!