| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLIRP |
| Gene ID: | 81892 |
| Uniprot ID: | SLIRP_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLIRP (NP_112487.1). |
| Immunogen Sequence: | MAASAARGAAALRRSINQPV AFVRRIPWTAASSQLKEHFA QFGHVRRCILPFDKETGFHR GLGWVQFSSEEGLRNALQQE NHIIDGVKVQVHTRRPKLPQ |
| Tissue Specificity | Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis. |
| Function | RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. |
| Protein Name | Sra Stem-Loop-Interacting Rna-Binding Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | MitochondrionNucleusPredominantly MitochondrialSome Fraction Is NuclearIn The NucleusIt Is Recruited To Nuclear Receptor Target Promoters |
| Alternative Antibody Names | Anti-Sra Stem-Loop-Interacting Rna-Binding Protein - Mitochondrial antibodyAnti-SLIRP antibodyAnti-C14orf156 antibodyAnti-DC23 antibodyAnti-DC50 antibodyAnti-PD04872 antibody |
Information sourced from Uniprot.org