Anti-SLIRP antibody (1-100) (STJ117719)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLIRP (1-100) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLIRP |
| Gene ID | 81892 |
| Uniprot ID | SLIRP_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MAASAARGAAALRRSINQPV AFVRRIPWTAASSQLKEHFA QFGHVRRCILPFDKETGFHR GLGWVQFSSEEGLRNALQQE NHIIDGVKVQVHTRRPKLPQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLIRP (NP_112487.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis. |
| Function | RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. |
| Protein Name | Sra Stem-Loop-Interacting Rna-Binding Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | MitochondrionNucleusPredominantly MitochondrialSome Fraction Is NuclearIn The NucleusIt Is Recruited To Nuclear Receptor Target Promoters |
| Alternative Antibody Names | Anti-Sra Stem-Loop-Interacting Rna-Binding Protein - Mitochondrial antibodyAnti-SLIRP antibodyAnti-C14orf156 antibodyAnti-DC23 antibodyAnti-DC50 antibodyAnti-PD04872 antibody |
Information sourced from Uniprot.org