Anti-SLFN11 antibody (150-200) {FITC} (STJ506361)

SKU:
STJ506361-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLFN11 (150-200) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: ELISA 1:10, 000
IP 1:200
WB 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLFN11
Gene ID: 91607
Uniprot ID: SLN11_HUMAN
Immunogen Region: 150-200
Immunogen: Synthetic peptide corresponding to amino acids within region 150-200 on human Schlafen family member 11 protein.
Tissue Specificity Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
Function Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.
Protein Name Schlafen Family Member 11
Cellular Localisation Nucleus
Chromosome
Recruited To Stressed Replication Forks Carrying Extended Rpa Filaments
Recruited To Dna Damage Sites Via Interaction With Rpa1
Alternative Antibody Names Anti-Schlafen Family Member 11 antibody
Anti-SLFN11 antibody

Information sourced from Uniprot.org

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