| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLCO1B1 (597-691) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLCO1B1 |
| Gene ID: |
10599 |
| Uniprot ID: |
SO1B1_HUMAN |
| Immunogen Region: |
597-691 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 597-691 of human SLCO1B1 (NP_006437.3). |
| Immunogen Sequence: |
TTCIKWSTNNCGTRGSCRTY NSTSFSRVYLGLSSMLRVSS LVLYIILIYAMKKKYQEKDI NASENGSVMDEANLESLNKN KHFVPSAGADSETHC |
| Tissue Specificity | Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Expressed in liver (at protein level). Expressed in fetal liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules. |
| Function | Mediates the Na(+)-independent uptake of organic anions. Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop. Involved in the clearance of endogenous and exogenous substrates from the liver. Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs. May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate. May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver. Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1b1Slco1b1Liver-Specific Organic Anion Transporter 1Lst-1Oatp-COrganic Anion Transporter Slc21a6Sodium-Independent Organic Anion-Transporting Polypeptide 2Oatp-2Solute Carrier Family 21 Member 6 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-189483Reactome: R-HSA-5619110Reactome: R-HSA-879518Reactome: R-HSA-9754706 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneDetected In Basolateral Membranes Of HepatocytesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Organic Anion Transporter Family Member 1b1 antibodyAnti-Slco1b1 antibodyAnti-Liver-Specific Organic Anion Transporter 1 antibodyAnti-Lst-1 antibodyAnti-Oatp-C antibodyAnti-Organic Anion Transporter Slc21a6 antibodyAnti-Sodium-Independent Organic Anion-Transporting Polypeptide 2 antibodyAnti-Oatp-2 antibodyAnti-Solute Carrier Family 21 Member 6 antibodyAnti-SLCO1B1 antibodyAnti-LST1 antibodyAnti-OATP1B1 antibodyAnti-OATP2 antibodyAnti-OATPC antibodyAnti-SLC21A6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
