Anti-SLC9A6 antibody (551-600) (STJ94482)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human SLC9A6. AA range:551-600
General Information
| Short Description | Rabbit polyclonal anti-Sodium/hydrogen exchanger 6/H+ exchanger 6 (551-600) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC9A6 |
| Gene ID | 10479 |
| Uniprot ID | SL9A6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC9A6. AA range:551-600 |
| Immunogen Region | 551-600 |
| Specificity | NHE-6 Polyclonal Antibody detects endogenous levels of NHE-6 protein. |
Additional Info
| Tissue Specificity | Ubiquitous. High expression in brain, skeletal muscle, and heart, but is also detected at lower levels in most other tissues. |
| Post Translational Modifications | Ubiquitinated (in vitro). Glycosylated. |
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo. Plays a critical role during neurodevelopment by regulating synaptic development and plasticity. Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH. Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane. |
| Protein Name | Sodium/Hydrogen Exchanger 6Na(+/H(+ Exchanger 6Nhe-6Solute Carrier Family 9 Member 6 |
| Database Links | Reactome: R-HSA-425986Reactome: R-HSA-5619092 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneEarly Endosome MembraneLate Endosome MembraneCell MembranePresent Predominantly In The Recycling Compartments Including Early And Recycling EndosomesBut Undergoes Plasma Membrane Localization During Vesicular RecyclingWhich Is Enhanced Upon Certain StimuliSuch As HypoxiaHas A Major Plasmalemmal Distribution In A Few Specialized CellsSuch As In Vestibular Hair Bundles And Osteoblasts |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 6 antibodyAnti-Na(+/H(+ Exchanger 6 antibodyAnti-Nhe-6 antibodyAnti-Solute Carrier Family 9 Member 6 antibodyAnti-SLC9A6 antibodyAnti-KIAA0267 antibodyAnti-NHE6 antibody |
Information sourced from Uniprot.org