Anti-SLC9A4 antibody (C-Term) (STJ13102117)

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STJ13102117-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SLC9A4 (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SLC9A4
Gene ID: 389015
Uniprot ID: SL9A4_HUMAN
Immunogen Region: C-Term
Specificity: Specific for SLC9A4.
Immunogen: A synthetic peptide from c-terminal region of human SLC9A4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Function Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions. As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion. Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion. Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids.
Protein Name Sodium/Hydrogen Exchanger 4
Na(+/H(+ Exchanger 4
Nhe-4
Solute Carrier Family 9 Member 4
Database Links Reactome: R-HSA-425986
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Zymogen Granule Membrane
Enrichment At Apical Or Basolateral Membrane May Be Tissue-Dependent
Alternative Antibody Names Anti-Sodium/Hydrogen Exchanger 4 antibody
Anti-Na(+/H(+ Exchanger 4 antibody
Anti-Nhe-4 antibody
Anti-Solute Carrier Family 9 Member 4 antibody
Anti-SLC9A4 antibody
Anti-NHE4 antibody

Information sourced from Uniprot.org

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