| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NHERF2 |
| Gene ID: | 9351 |
| Uniprot ID: | NHRF2_HUMAN |
| Immunogen Region: | 180-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human SLC9A3R2 (NP_001123484). |
| Immunogen Sequence: | DPGSPAARSGLRAQDRLIEV NGQNVEGLRHAEVVASIKAR EDEARLLVVDPETDEHFKRL RVTPTEEHVEGPLPSPVTNG TSPAQLNGGSACSSRSDLPG SDKDTEDGSAWKQDPFQESG L |
| Tissue Specificity | Widely expressed. |
| Function | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf2 Nherf-2 Nhe3 Kinase A Regulatory Protein E3karp Sry-Interacting Protein 1 Sip-1 Sodium-Hydrogen Exchanger Regulatory Factor 2 Solute Carrier Family 9 Isoform A3 Regulatory Factor 2 Tyrosine Kinase Activator Protein 1 Tka-1 |
| Cellular Localisation | Endomembrane System Peripheral Membrane Protein Nucleus Apical Cell Membrane Localizes With Ezr And Podxl At The Apical Cell Membrane Of Glomerular Epithelium Cells And The Sides Of The Food Processes Nuclear In A Punctate Pattern |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf2 antibody Anti-Nherf-2 antibody Anti-Nhe3 Kinase A Regulatory Protein E3karp antibody Anti-Sry-Interacting Protein 1 antibody Anti-Sip-1 antibody Anti-Sodium-Hydrogen Exchanger Regulatory Factor 2 antibody Anti-Solute Carrier Family 9 Isoform A3 Regulatory Factor 2 antibody Anti-Tyrosine Kinase Activator Protein 1 antibody Anti-Tka-1 antibody Anti-NHERF2 antibody Anti-SLC9A3R2 antibody |
Information sourced from Uniprot.org