| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC9A3R1 (189-358) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:4000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NHERF1 |
| Gene ID: |
9368 |
| Uniprot ID: |
NHRF1_HUMAN |
| Immunogen Region: |
189-358 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SLC9A3R1 (NP_004243.1). |
| Immunogen Sequence: |
EASGLRAQDRIVEVNGVCME GKQHGDVVSAIRAGGDETKL LVVDRETDEFFKKCRVIPSQ EHLNGPLPVPFTNGEIQKEN SREALAEAALESPRPALVRS ASSDTSEELNSQDSPPKQDS TAPSSTSSSDPILDFNISLA MAKERAHQKRSSKRAPQMDW SKKNELFSNL |
| Tissue Specificity | Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf1Nherf-1Ezrin-Radixin-Moesin-Binding Phosphoprotein 50Ebp50Regulatory Cofactor Of Na(+/H(+ ExchangerSodium-Hydrogen Exchanger Regulatory Factor 1Solute Carrier Family 9 Isoform A3 Regulatory Factor 1 |
| Cellular Localisation | CytoplasmApical Cell MembraneEndomembrane SystemPeripheral Membrane ProteinCell ProjectionFilopodiumRuffleMicrovillusTranslocates From The Cytoplasm To The Apical Cell Membrane In A Podxl-Dependent MannerColocalizes With Cftr At The Midpiece Of Sperm TailColocalizes With Actin In Microvilli-Rich Apical Regions Of The SyncytiotrophoblastFound In MicrovilliRuffling Membrane And Filopodia Of Hela CellsPresent In Lipid Rafts Of T-Cells |
| Alternative Antibody Names | Anti-Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf1 antibodyAnti-Nherf-1 antibodyAnti-Ezrin-Radixin-Moesin-Binding Phosphoprotein 50 antibodyAnti-Ebp50 antibodyAnti-Regulatory Cofactor Of Na(+/H(+ Exchanger antibodyAnti-Sodium-Hydrogen Exchanger Regulatory Factor 1 antibodyAnti-Solute Carrier Family 9 Isoform A3 Regulatory Factor 1 antibodyAnti-NHERF1 antibodyAnti-NHERF antibodyAnti-SLC9A3R1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
