| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:6000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC8A1 |
| Gene ID: | 6546 |
| Uniprot ID: | NAC1_HUMAN |
| Immunogen Region: | 600-700 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-700 of human SLC8A1 (NP_066920.1). |
| Immunogen Sequence: | DEIVKTISVKVIDDEEYEKN KTFFLEIGEPRLVEMSEKKA LLLNELGGFTITGKYLFGQP VFRKVHAREHPILSTVITIA DEYDDKQPLTSKEEEERRIA E |
| Tissue Specificity | Detected primarily in heart and at lower levels in brain. Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. |
| Function | Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. |
| Protein Name | Sodium/Calcium Exchanger 1 Na(+/Ca(2+-Exchange Protein 1 Solute Carrier Family 8 Member 1 |
| Database Links | Reactome: R-HSA-418359 Reactome: R-HSA-425561 Reactome: R-HSA-5578775 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Calcium Exchanger 1 antibody Anti-Na(+/Ca(2+-Exchange Protein 1 antibody Anti-Solute Carrier Family 8 Member 1 antibody Anti-SLC8A1 antibody Anti-CNC antibody Anti-NCX1 antibody |
Information sourced from Uniprot.org