| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SLC7A7 |
| Gene ID: |
9056 |
| Uniprot ID: |
YLAT1_HUMAN |
| Immunogen Region: |
452-511 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 452-511 of human SLC7A7 (NP_001119577.1). |
| Immunogen Sequence: |
SGLPFYFLIIRVPEHKRPLY LRRIVGSATRYLQVLCMSVA AEMDLEDGGEMPKQRDPKSN |
| Tissue Specificity | Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line. |
| Function | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine. Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1. In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids. |
| Protein Name | Y+L Amino Acid Transporter 1Monocyte Amino Acid Permease 2Mop-2Solute Carrier Family 7 Member 7Y(+L-Type Amino Acid Transporter 1Y+Lat1Y+Lat-1 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230Reactome: R-HSA-5660862 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Y+L Amino Acid Transporter 1 antibodyAnti-Monocyte Amino Acid Permease 2 antibodyAnti-Mop-2 antibodyAnti-Solute Carrier Family 7 Member 7 antibodyAnti-Y(+L-Type Amino Acid Transporter 1 antibodyAnti-Y+Lat1 antibodyAnti-Y+Lat-1 antibodyAnti-SLC7A7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
