| Tissue Specificity | Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine. Expressed in a subpopulation of astrocytes enriched at glycinergic synapses in the spinal cord and brainstem (at protein level). Expressed in OLIG2-positive astrocytes of the lateral globus pallidus (at protein level). Expressed in CD34-positive, DPP4-positive mesenchymal progenitors in developing subcutaneous adipose tissue. |
| Function | Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment. |
| Protein Name | Asc-Type Amino Acid Transporter 1Asc-1D-Serine TransporterSolute Carrier Family 7 Member 10 |
| Database Links | Reactome: R-MMU-210991Reactome: -MMU-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinColocalizes With Olig2 In Astrocytic ProcessesLocalizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes |
| Alternative Antibody Names | Anti-Asc-Type Amino Acid Transporter 1 antibodyAnti-Asc-1 antibodyAnti-D-Serine Transporter antibodyAnti-Solute Carrier Family 7 Member 10 antibodyAnti-Slc7a10 antibodyAnti-Asc1 antibody |
Information sourced from Uniprot.org
