| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC6A5 |
| Gene ID: | 9152 |
| Uniprot ID: | SC6A5_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SLC6A5 (NP_004202.3). |
| Immunogen Sequence: | MDCSAPKEMNKLPANSPEAA AAQGHPDGPCAPRTSPEQEL PAAAAPPPPRVPRSASTGAQ TFQSADARACEAERPGVGSC KLSSPRAQAASAALRDLREA QGAQASPPPGSSGPGNALHC KIPFLRGPEGDANVSVGKGT LERNNTPVVGWVNMSQSTVV LGTDGITSVLPGSVATVATQ EDEQGDENKARGNWSSKLDF |
| Tissue Specificity | Expressed in medulla, and to a lesser extent in spinal cord and cerebellum. |
| Post Translational Modifications | N-glycosylated. |
| Function | Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. Isoform 2: Lacks sodium- and chloride-dependent glycine transporter activity. Isoform 3: Lacks sodium- and chloride-dependent glycine transporter activity. |
| Protein Name | Sodium- And Chloride-Dependent Glycine Transporter 2Glyt-2Glyt2Solute Carrier Family 6 Member 5 |
| Database Links | Reactome: R-HSA-442660Reactome: R-HSA-5619089 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Glycine Transporter 2 antibodyAnti-Glyt-2 antibodyAnti-Glyt2 antibodyAnti-Solute Carrier Family 6 Member 5 antibodyAnti-SLC6A5 antibodyAnti-GLYT2 antibodyAnti-NET1 antibody |
Information sourced from Uniprot.org