| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SLC6A3/DAT (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 85kDa band observed in Human Brain (Substantia nigra) lysates (calculated MW of 68.5kDa according to NP_001035.1). The observed molecular weight corresponds to earlier findings i |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SLC6A3 |
| Gene ID: | 6531 |
| Uniprot ID: | SC6A3_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001035.1 |
| Immunogen Sequence: | QLTSSTLTNPRQSP |
| Function | Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling. |
| Protein Name | Sodium-Dependent Dopamine TransporterDa TransporterDatSolute Carrier Family 6 Member 3 |
| Database Links | Reactome: R-HSA-379401Reactome: R-HSA-442660Reactome: R-HSA-5619081Reactome: R-HSA-5660724 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionNeuron ProjectionAxonLocalizes To Neurite Tips In Neuronal CellsColocalizes With Septin4 At Axon TerminalsEspecially At The Varicosities |
| Alternative Antibody Names | Anti-Sodium-Dependent Dopamine Transporter antibodyAnti-Da Transporter antibodyAnti-Dat antibodyAnti-Solute Carrier Family 6 Member 3 antibodyAnti-SLC6A3 antibodyAnti-DAT1 antibody |
Information sourced from Uniprot.org
