Anti-SLC6A12/BGT1 antibody (C-Term) (STJ72918)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SLC6A12/BGT1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 70kDa band observed in Human Brain lysates from several regions (calculated MW of 69.4kDa according to NP_003035.3). Recommended concentration: 1-3ยตg/ml. An additional band of |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC6A12 |
| Gene ID | 6539 |
| Uniprot ID | S6A12_HUMAN |
| Accession Number | NP_003035.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | CLDGSAGRNFGPSPT |
| Specificity | Reported variants represent identical protein: NP_001193860.1, NP_003035.3, NP_001116319.1, NP_001116320.1. |
Additional Info
| Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation. |
| Protein Name | Sodium- And Chloride-Dependent Betaine TransporterBgt-1Na(+/Cl(- Betaine/Gaba TransporterSolute Carrier Family 6 Member 12 |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-442660Reactome: R-HSA-71288Reactome: R-HSA-888593 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCell MembraneIn KidneyLocates In Basolateral Membranes Of Renal MedullaIn LiverLocates In Hepatocytes Cell Membrane |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Betaine Transporter antibodyAnti-Bgt-1 antibodyAnti-Na(+/Cl(- Betaine/Gaba Transporter antibodyAnti-Solute Carrier Family 6 Member 12 antibodyAnti-SLC6A12 antibodyAnti-BGT1 antibody |
Information sourced from Uniprot.org