| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SLC6A12/BGT1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000. WB: Approx 70kDa band observed in Human Brain lysates from several regions (calculated MW of 69.4kDa according to NP_003035.3). Recommended concentration: 1-3µg/ml. An additional band of |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SLC6A12 |
| Gene ID: | 6539 |
| Uniprot ID: | S6A12_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_003035.3 |
| Specificity: | Reported variants represent identical protein: NP_001193860.1, NP_003035.3, NP_001116319.1, NP_001116320.1. |
| Immunogen Sequence: | CLDGSAGRNFGPSPT |
| Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation. |
| Protein Name | Sodium- And Chloride-Dependent Betaine Transporter Bgt-1 Na(+/Cl(- Betaine/Gaba Transporter Solute Carrier Family 6 Member 12 |
| Database Links | Reactome: R-HSA-352230 Reactome: R-HSA-442660 Reactome: R-HSA-71288 Reactome: R-HSA-888593 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Cell Membrane In Kidney Locates In Basolateral Membranes Of Renal Medulla In Liver Locates In Hepatocytes Cell Membrane |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Betaine Transporter antibody Anti-Bgt-1 antibody Anti-Na(+/Cl(- Betaine/Gaba Transporter antibody Anti-Solute Carrier Family 6 Member 12 antibody Anti-SLC6A12 antibody Anti-BGT1 antibody |
Information sourced from Uniprot.org