| Short Description : | Rabbit polyclonal anti-Sodium-and chloride-dependent betaine transporter/Cl-betaine/GABA transporter for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC6A12 |
| Gene ID: | 6539 |
| Uniprot ID: | S6A12_HUMAN |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Specificity: | S6A12 Polyclonal Antibody detects endogenous levels of protein. |
| Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation. |
| Protein Name | Sodium- And Chloride-Dependent Betaine TransporterBgt-1Na(+/Cl(- Betaine/Gaba TransporterSolute Carrier Family 6 Member 12 |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-442660Reactome: R-HSA-71288Reactome: R-HSA-888593 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCell MembraneIn KidneyLocates In Basolateral Membranes Of Renal MedullaIn LiverLocates In Hepatocytes Cell Membrane |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Betaine Transporter antibodyAnti-Bgt-1 antibodyAnti-Na(+/Cl(- Betaine/Gaba Transporter antibodyAnti-Solute Carrier Family 6 Member 12 antibodyAnti-SLC6A12 antibodyAnti-BGT1 antibody |
Information sourced from Uniprot.org
