| Function | Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity. Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney. |
| Protein Name | Sodium/Glucose Cotransporter 2Na(+/Glucose Cotransporter 2Low Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 2 |
| Database Links | Reactome: R-HSA-189200Reactome: R-HSA-5658208 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Glucose Cotransporter 2 antibodyAnti-Na(+/Glucose Cotransporter 2 antibodyAnti-Low Affinity Sodium-Glucose Cotransporter antibodyAnti-Solute Carrier Family 5 Member 2 antibodyAnti-SLC5A2 antibodyAnti-SGLT2 antibody |
Information sourced from Uniprot.org
