| Tissue Specificity | Highest expression observed in liver, spleen and testis.moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. Isoform 3: Expressed in the brain, heart, kidney, testis, pancreas, muscle and peripheral blood leukocytes. |
| Function | Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. |
| Protein Name | Electrogenic Sodium Bicarbonate Cotransporter 4Nbce2Solute Carrier Family 4 Member 5 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneExpressed In The Apical Plasma Membrane Domain Of A Subset Of Collecting Ducts In The Renal Medulla |
| Alternative Antibody Names | Anti-Electrogenic Sodium Bicarbonate Cotransporter 4 antibodyAnti-Nbce2 antibodyAnti-Solute Carrier Family 4 Member 5 antibodyAnti-SLC4A5 antibodyAnti-NBC4 antibody |
Information sourced from Uniprot.org
