Anti-SLC4A2 antibody (200-300) (STJ110040)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC4A2 (200-300) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC4A2 |
| Gene ID | 6522 |
| Uniprot ID | B3A2_HUMAN |
| Immunogen Region | 200-300 |
| Immunogen Sequence | DDGGASGRPLPKAQPGHRSY NLQERRRIGSMTGAEQALLP RVPTDEIEAQTLATADLDLM KSHRFEDVPGVRRHLVRKNA KGSTQSGREGREPGPTPRAR P |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human SLC4A2 (NP_001186623.1). |
Additional Info
| Tissue Specificity | Isoform A: Expressed in the liver, stomach, kidney, prostate, thyroid and rectum. Isoform B1: Expressed in the liver and kidney. Isoform B2: Expressed in the liver and kidney. |
| Function | Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function. Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH. Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses. |
| Protein Name | Anion Exchange Protein 2Ae 2Anion Exchanger 2Non-Erythroid Band 3-Like ProteinBnd3lSolute Carrier Family 4 Member 2 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Isoform A: Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneIsoform B1: Apical Cell MembraneIsoform B2: Apical Cell Membrane |
| Alternative Antibody Names | Anti-Anion Exchange Protein 2 antibodyAnti-Ae 2 antibodyAnti-Anion Exchanger 2 antibodyAnti-Non-Erythroid Band 3-Like Protein antibodyAnti-Bnd3l antibodyAnti-Solute Carrier Family 4 Member 2 antibodyAnti-SLC4A2 antibodyAnti-AE2 antibodyAnti-EPB3L1 antibodyAnti-HKB3 antibodyAnti-MPB3L antibody |
Information sourced from Uniprot.org