Anti-SLC4A1 antibody (STJA0008011)

SKU:
STJA0008011

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Band 3 anion transport protein is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC4A1
Gene ID: 6521
Uniprot ID: B3AT_HUMAN
Specificity: This antibody detects endogenous levels of Band 3/AE1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human Band 3/AE1
Post Translational Modifications Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation. Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation. N-glycosylated.
Function Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane.required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes.
Protein Name Band 3 Anion Transport Protein
Anion Exchange Protein 1
Ae 1
Anion Exchanger 1
Solute Carrier Family 4 Member 1
Cd Antigen Cd233
Database Links Reactome: R-HSA-1237044
Reactome: R-HSA-1247673
Reactome: R-HSA-425381
Reactome: R-HSA-5619050
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Detected In The Erythrocyte Cell Membrane And On The Basolateral Membrane Of Alpha-Intercalated Cells In The Collecting Duct In The Kidney
Alternative Antibody Names Anti-Band 3 Anion Transport Protein antibody
Anti-Anion Exchange Protein 1 antibody
Anti-Ae 1 antibody
Anti-Anion Exchanger 1 antibody
Anti-Solute Carrier Family 4 Member 1 antibody
Anti-Cd Antigen Cd233 antibody
Anti-SLC4A1 antibody
Anti-AE1 antibody
Anti-DI antibody
Anti-EPB3 antibody

Information sourced from Uniprot.org

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