| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Solute carrier family 40 member 1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC40A1 |
| Gene ID: |
30061 |
| Uniprot ID: |
S40A1_HUMAN |
| Immunogen Region: |
1-100 |
| Specificity: |
This antibody detects endogenous levels of SLC40A1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human SLC40A1. AA range 1-100 |
| Post Translational Modifications | Polyubiquitinated by RNF217.leading to proteasomal degradation. Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells. |
| Function | Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. |
| Protein Name | FerroportinFerroportin-1Iron-Regulated Transporter 1Solute Carrier Family 40 Member 1 |
| Database Links | Reactome: R-HSA-425410Reactome: R-HSA-5619049Reactome: R-HSA-5619060Reactome: R-HSA-5655799Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalized To The Basolateral Membrane Of Hepatocytoma Wif-B Cells |
| Alternative Antibody Names | Anti-Ferroportin antibodyAnti-Ferroportin-1 antibodyAnti-Iron-Regulated Transporter 1 antibodyAnti-Solute Carrier Family 40 Member 1 antibodyAnti-SLC40A1 antibodyAnti-FPN antibodyAnti-FPN1 antibodyAnti-IREG1 antibodyAnti-SLC11A3 antibodyAnti-MSTP079 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
