| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC3A1 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC3A1 |
| Gene ID: |
6519 |
| Uniprot ID: |
SLC31_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for SLC3A1. |
| Immunogen: |
A synthetic peptide from internal region of human Neutral and basic amino acid transport protein rBAT (SLC3A1, D2h) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporter heteromers to the plasma membrane. Associates with SLC7A9 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1. SLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine. SLC7A9-SLC3A1 acts as a major transporter for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in early proximal tubules. Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion. SLC7A13-SLC3A1 may act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate. |
| Protein Name | Amino Acid Transporter Heavy Chain Slc3a1D2hNeutral And Basic Amino Acid Transport ProteinNbatSolute Carrier Family 3 Member 1B(0 -+-Type Amino Acid Transporter-Related Heavy ChainRbat |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-5619113Reactome: R-HSA-5660883 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Amino Acid Transporter Heavy Chain Slc3a1 antibodyAnti-D2h antibodyAnti-Neutral And Basic Amino Acid Transport Protein antibodyAnti-Nbat antibodyAnti-Solute Carrier Family 3 Member 1 antibodyAnti-B(0 -+-Type Amino Acid Transporter-Related Heavy Chain antibodyAnti-Rbat antibodyAnti-SLC3A1 antibodyAnti-NBAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
