| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC39A6 (400-500 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SLC39A6 |
| Gene ID: |
25800 |
| Uniprot ID: |
S39A6_HUMAN |
| Immunogen Region: |
400-500 aa |
| Specificity: |
Specific for SLC39A6. |
| Immunogen: |
A synthetic peptide from aa region 400-500 human SLC39A6 conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Cleaved on the N-terminus before locating to the plasma membrane. N-glycosylated. Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. |
| Function | Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition. |
| Protein Name | Zinc Transporter Zip6Estrogen-Regulated Protein Liv-1Solute Carrier Family 39 Member 6Zrt- And Irt-Like Protein 6Zip-6 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionLamellipodium MembraneMembrane RaftApical Cell MembraneLocalizes To Lipid Rafts In T Cells And Is Recruited Into The Immunological Synapse In Response To Tcr StimulationIn The Choroid Plexus Is Limited To The Apical Membrane In Epithelial Cells |
| Alternative Antibody Names | Anti-Zinc Transporter Zip6 antibodyAnti-Estrogen-Regulated Protein Liv-1 antibodyAnti-Solute Carrier Family 39 Member 6 antibodyAnti-Zrt- And Irt-Like Protein 6 antibodyAnti-Zip-6 antibodyAnti-SLC39A6 antibodyAnti-LIV1 antibodyAnti-ZIP6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
