Anti-SLC38A2 antibody (151-200 aa) (STJ95719)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SLC38A2 at the amino acid range 151-200
General Information
| Short Description | Rabbit polyclonal anti-Sodium-coupled neutral amino acid symporter 2 (151-200 aa) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC38A2 |
| Gene ID | 54407 |
| Uniprot ID | S38A2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SLC38A2 at the amino acid range 151-200 |
| Immunogen Region | 151-200 aa |
| Specificity | SNAT2 Polyclonal Antibody detects endogenous levels of SNAT2 protein. |
Additional Info
| Post Translational Modifications | Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. |
| Function | Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier. May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta. Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate. Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Symporter 2Amino Acid Transporter A2Protein 40-9-1Solute Carrier Family 38 Member 2System A Amino Acid Transporter 2System A Transporter 1System N Amino Acid Transporter 2 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInsulin Promotes Recruitment To The Plasma Membrane From A Pool Localized In The Trans-Golgi Network Or EndosomesEnriched In The Somatodendritic Compartment Of NeuronsIt Is Also Detected At The Axonal Shaft But Excluded From The Nerve Terminal |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Symporter 2 antibodyAnti-Amino Acid Transporter A2 antibodyAnti-Protein 40-9-1 antibodyAnti-Solute Carrier Family 38 Member 2 antibodyAnti-System A Amino Acid Transporter 2 antibodyAnti-System A Transporter 1 antibodyAnti-System N Amino Acid Transporter 2 antibodyAnti-SLC38A2 antibodyAnti-ATA2 antibodyAnti-KIAA1382 antibodyAnti-SAT2 antibodyAnti-SNAT2 antibody |
Information sourced from Uniprot.org