| Post Translational Modifications | Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. |
| Function | Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier. May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta. Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate. Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Symporter 2Amino Acid Transporter A2Protein 40-9-1Solute Carrier Family 38 Member 2System A Amino Acid Transporter 2System A Transporter 1System N Amino Acid Transporter 2 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInsulin Promotes Recruitment To The Plasma Membrane From A Pool Localized In The Trans-Golgi Network Or EndosomesEnriched In The Somatodendritic Compartment Of NeuronsIt Is Also Detected At The Axonal Shaft But Excluded From The Nerve Terminal |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Symporter 2 antibodyAnti-Amino Acid Transporter A2 antibodyAnti-Protein 40-9-1 antibodyAnti-Solute Carrier Family 38 Member 2 antibodyAnti-System A Amino Acid Transporter 2 antibodyAnti-System A Transporter 1 antibodyAnti-System N Amino Acid Transporter 2 antibodyAnti-SLC38A2 antibodyAnti-ATA2 antibodyAnti-KIAA1382 antibodyAnti-SAT2 antibodyAnti-SNAT2 antibody |
Information sourced from Uniprot.org
