| Function | Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar. Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides. May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development. |
| Protein Name | Nucleotide Sugar Transporter Slc35d1Solute Carrier Family 35 Member D1Udp-Galactose Transporter-Related Protein 7Ugtrel7Udp-Glucuronic Acid/Udp-N-Acetylgalactosamine TransporterUdp-Glca/Udp-Galnac Transporter |
| Database Links | Reactome: R-HSA-173599Reactome: R-HSA-5579020Reactome: R-HSA-727802 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Nucleotide Sugar Transporter Slc35d1 antibodyAnti-Solute Carrier Family 35 Member D1 antibodyAnti-Udp-Galactose Transporter-Related Protein 7 antibodyAnti-Ugtrel7 antibodyAnti-Udp-Glucuronic Acid/Udp-N-Acetylgalactosamine Transporter antibodyAnti-Udp-Glca/Udp-Galnac Transporter antibodyAnti-SLC35D1 antibodyAnti-KIAA0260 antibodyAnti-UGTREL7 antibody |
Information sourced from Uniprot.org
