Anti-SLC32A1 antibody (N-Term) (STJA0003822)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH.
General Information
| Short Description | Rabbit polyclonal anti-VGAT (N-Term) for use in WB, IHC and ICC in Chicken, Mouse, Rat, Xenopus, Bovine, Canine and Non-Human Primates samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Rabbit |
| Reactivity | Chicken/Mouse/Rat/Xenopus/Bovine/Canine/Non-Human Primates |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000IHC 1:100-1:1000ICC 1:500 |
| Formulation | 100 ยตl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 ยตg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Slc32a1 |
| Gene ID | 83612 |
| Uniprot ID | VIAAT_RAT |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. |
| Immunogen Region | N-Term |
Additional Info
| Tissue Specificity | Brain. Expressed at high levels within the neocortex, hippocampus, cerebellum, striatum, septal nuclei and the reticular nucleus of the thalamus. Also expressed in islets where it is more abundant in the peripheral/mantle region. Highly expressed in the nerve endings of GABA neurons in the brain and spinal cord but also in glycinergic nerve endings. Expressed in glycine-, GABA- or GABA- and glycine-containing boutons. |
| Function | Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake. |
| Protein Name | Vesicular Inhibitory Amino Acid TransporterGaba And Glycine TransporterSolute Carrier Family 32 Member 1Vesicular Gaba TransporterRgvatRat Unc-47 HomologRunc-47 |
| Database Links | Reactome: R-RNO-425393Reactome: -RNO-888590 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane ProteinPresynapsePresents In Glycine-Gaba- Or Gaba- And Glycine-Containing Boutons |
| Alternative Antibody Names | Anti-Vesicular Inhibitory Amino Acid Transporter antibodyAnti-Gaba And Glycine Transporter antibodyAnti-Solute Carrier Family 32 Member 1 antibodyAnti-Vesicular Gaba Transporter antibodyAnti-Rgvat antibodyAnti-Rat Unc-47 Homolog antibodyAnti-Runc-47 antibodyAnti-Slc32a1 antibodyAnti-Vgat antibodyAnti-Viaat antibody |
Information sourced from Uniprot.org