Anti-SLC31A2 antibody (10-60 aa) (STJ194332)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human COPT2 at the amino acid range 10-60
General Information
| Short Description | Rabbit polyclonal anti-Protein SLC31A2 (10-60 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC31A2 |
| Gene ID | 1318 |
| Uniprot ID | COPT2_HUMAN |
| Immunogen | Synthesized peptide derived from the human COPT2 at the amino acid range 10-60 |
| Immunogen Region | 10-60 aa |
| Specificity | This antibody detects endogenous levels of COPT2 at Human/Mouse |
Additional Info
| Post Translational Modifications | Ubiquitinated.ubiquitination and the subsequent proteasomal degradation are prevent by SLC31A1 that stabilizes it. |
| Function | Does not function as a copper(1+) importer in vivo. However, in vitro functions as a low-affinity copper(1+) importer. Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1. |
| Protein Name | Protein Slc31a2Copper Transporter 2Hctr2Solute Carrier Family 31 Member 2 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneLate Endosome MembraneLysosome MembranePlasma Membrane Localization Is Partial |
| Alternative Antibody Names | Anti-Protein Slc31a2 antibodyAnti-Copper Transporter 2 antibodyAnti-Hctr2 antibodyAnti-Solute Carrier Family 31 Member 2 antibodyAnti-SLC31A2 antibodyAnti-COPT2 antibodyAnti-CTR2 antibody |
Information sourced from Uniprot.org