Host: | Rabbit |
Applications: | IHC/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Solute Carrier Family 2-Facilitated Glucose Transporter Member 4 (210-310) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | IHC-P 1:50-1:200 IF/ICC 1:100-1:500 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | SLC2A4 |
Gene ID: | 6517 |
Uniprot ID: | GLUT4_HUMAN |
Immunogen Region: | 210-310 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 210-310 of human GLUT4 (NP_001033.1). |
Immunogen Sequence: | VLPALLQLVLLPFCPESPRY LYIIQNLEGPARKSLKRLTG WADVSGVLAELKDEKRKLER ERPLSLLQLLGSRTHRQPLI IAVVLQLSQQLSGINAVFYY S |
Tissue Specificity | Skeletal and cardiac muscles.brown and white fat. |
Post Translational Modifications | Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. |
Function | Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. |
Protein Name | Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4 Glucose Transporter Type 4 - Insulin-Responsive Glut-4 |
Database Links | Reactome: R-HSA-1445148 Reactome: R-HSA-189200 Reactome: R-HSA-381340 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Endomembrane System Cytoplasm Perinuclear Region Localizes Primarily To The Perinuclear Region Undergoing Continued Recycling To The Plasma Membrane Where It Is Rapidly Reinternalized The Dileucine Internalization Motif Is Critical For Intracellular Sequestration Insulin Stimulation Induces Translocation To The Cell Membrane |
Alternative Antibody Names | Anti-Solute Carrier Family 2 - Facilitated Glucose Transporter Member 4 antibody Anti-Glucose Transporter Type 4 - Insulin-Responsive antibody Anti-Glut-4 antibody Anti-SLC2A4 antibody Anti-GLUT4 antibody |
Information sourced from Uniprot.org