| Post Translational Modifications | N-glycosylated. |
| Function | Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs. Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations. Functions as a Na(+)- and Cl(-)-independent bidirectional transporter. Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure. Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system. Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain. Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney. Also transports guanidine. |
| Protein Name | Equilibrative Nucleoside Transporter 4Hent4Plasma Membrane Monoamine TransporterPmatSolute Carrier Family 29 Member 4 |
| Database Links | Reactome: R-HSA-83936 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocated To The Plasma Membranes Of Ventricular Myocytes And Vascular Endothelial CellsTargeted To The Apical Membranes Of Differentiated Kidney Epithelial CellsLocalized To The Apical Blood-Cerebrospinal Fluid (Csf)-Facing Membrane Of The Choroid Plexus Epithelium |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 4 antibodyAnti-Hent4 antibodyAnti-Plasma Membrane Monoamine Transporter antibodyAnti-Pmat antibodyAnti-Solute Carrier Family 29 Member 4 antibodyAnti-SLC29A4 antibodyAnti-ENT4 antibodyAnti-PMAT antibodyAnti-PSEC0113 antibody |
Information sourced from Uniprot.org
