| Function | Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments. Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids. Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine. Capable of transporting ATP. Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers. |
| Protein Name | Equilibrative Nucleoside Transporter 3Hent3Solute Carrier Family 29 Member 3 |
| Database Links | Reactome: R-HSA-5619063Reactome: R-HSA-83936Reactome: R-HSA-9755088 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinLate Endosome MembraneMitochondrion MembraneCell MembraneObserved In A Punctate Intracellular Pattern Showing Partial Colocalization With Late Endosomes/LysosomesDetected At The Cell Surface Only In Certain Placental Cells |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 3 antibodyAnti-Hent3 antibodyAnti-Solute Carrier Family 29 Member 3 antibodyAnti-SLC29A3 antibodyAnti-ENT3 antibodyAnti-UNQ717 antibodyAnti-PRO1380 antibody |
Information sourced from Uniprot.org
