Anti-SLC29A3 antibody (1-60) {FITC} (STJ500887)

SKU:
STJ500887-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Bovine/Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC29A3 (1-60) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.61 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC29A3
Gene ID: 55315
Uniprot ID: S29A3_HUMAN
Immunogen Region: 1-60
Immunogen: Synthetic peptide taken within amino acid region 1-60 on ENT3 protein.
Tissue Specificity Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Expressed in liver. Lowest levels in brain and heart. Expressed in macrophages.
Function Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments. Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids. Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine. Capable of transporting ATP. Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers.
Protein Name Equilibrative Nucleoside Transporter 3
Hent3
Solute Carrier Family 29 Member 3
Database Links Reactome: R-HSA-5619063
Reactome: R-HSA-83936
Reactome: R-HSA-9755088
Cellular Localisation Lysosome Membrane
Multi-Pass Membrane Protein
Late Endosome Membrane
Mitochondrion Membrane
Cell Membrane
Observed In A Punctate Intracellular Pattern Showing Partial Colocalization With Late Endosomes/Lysosomes
Detected At The Cell Surface Only In Certain Placental Cells
Alternative Antibody Names Anti-Equilibrative Nucleoside Transporter 3 antibody
Anti-Hent3 antibody
Anti-Solute Carrier Family 29 Member 3 antibody
Anti-SLC29A3 antibody
Anti-ENT3 antibody
Anti-UNQ717 antibody
Anti-PRO1380 antibody

Information sourced from Uniprot.org

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