| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SLC29A1 (200-260 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | SLC29A1 |
| Gene ID: | 2030 |
| Uniprot ID: | S29A1_HUMAN |
| Immunogen Region: | 200-260 aa |
| Specificity: | Specific for SLC29A1. |
| Immunogen: | A synthetic peptide from aa region 200-260 of human SLC29A1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Glycosylated. |
| Function | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier. Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure. |
| Protein Name | Equilibrative Nucleoside Transporter 1 Hent1 Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter Equilibrative Nbmpr-Sensitive Nucleoside Transporter Es Nucleoside Transporter Nucleoside Transporter - Es-Type Solute Carrier Family 29 Member 1 |
| Database Links | Reactome: R-HSA-83936 Reactome: R-HSA-9748787 Reactome: R-HSA-9755088 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Cell Membrane Localized To The Basolateral Membrane Of Sertoli Cells Localized To The Cell Membrane Of Erythrocytes |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 1 antibody Anti-Hent1 antibody Anti-Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter antibody Anti-Equilibrative Nbmpr-Sensitive Nucleoside Transporter antibody Anti-Es Nucleoside Transporter antibody Anti-Nucleoside Transporter - Es-Type antibody Anti-Solute Carrier Family 29 Member 1 antibody Anti-SLC29A1 antibody Anti-ENT1 antibody |
Information sourced from Uniprot.org
