| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC26A2 |
| Gene ID: | 1836 |
| Uniprot ID: | S26A2_HUMAN |
| Immunogen Region: | 1-111 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human SLC26A2 (NP_000103.2). |
| Immunogen Sequence: | MSSESKEQHNVSPRDSAEGN DSYPSGIHLELQRESSTDFK QFETNDQCRPYHRILIERQE KSDTNFKEFVIKKLQKNCQC SPAKAKNMILGFLPVLQWLP KYDLKKNILGD |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | N-glycosylated. |
| Function | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions. Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions. The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange. Essential for chondrocyte proliferation, differentiation and cell size expansion. |
| Protein Name | Sulfate Transporter Diastrophic Dysplasia Protein Solute Carrier Family 26 Member 2 |
| Database Links | Reactome: R-HSA-174362 Reactome: R-HSA-3560792 Reactome: R-HSA-427601 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane |
| Alternative Antibody Names | Anti-Sulfate Transporter antibody Anti-Diastrophic Dysplasia Protein antibody Anti-Solute Carrier Family 26 Member 2 antibody Anti-SLC26A2 antibody Anti-DTD antibody Anti-DTDST antibody |
Information sourced from Uniprot.org