Anti-SLC25A6 antibody (121-170 aa) (STJ91606)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SLC25A6 at the amino acid range 121-170
General Information
| Short Description | Rabbit polyclonal anti-ADP/ATP translocase 3 (121-170 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A6 |
| Gene ID | 293 |
| Uniprot ID | ADT3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SLC25A6 at the amino acid range 121-170 |
| Immunogen Region | 121-170 aa |
| Specificity | ANT3 Polyclonal Antibody detects endogenous levels of ANT3 protein. |
Additional Info
| Post Translational Modifications | Trimethylated by ANTKMT at Lys-52. |
| Function | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it. |
| Protein Name | Adp/Atp Translocase 3Adp -Atp Carrier Protein 3Adp -Atp Carrier Protein - Isoform T2Ant 2Adenine Nucleotide Translocator 3Ant 3Solute Carrier Family 25 Member 6 Cleaved Into - Adp/Atp Translocase 3 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-168277Reactome: R-HSA-180897Reactome: R-HSA-83936Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinMembraneThe Complex Formed With Arl2bpArl2 And Slc25a6/Ant3 Is Expressed In MitochondriaMay Localize To Non-Mitochondrial Membranes |
| Alternative Antibody Names | Anti-Adp/Atp Translocase 3 antibodyAnti-Adp -Atp Carrier Protein 3 antibodyAnti-Adp -Atp Carrier Protein - Isoform T2 antibodyAnti-Ant 2 antibodyAnti-Adenine Nucleotide Translocator 3 antibodyAnti-Ant 3 antibodyAnti-Solute Carrier Family 25 Member 6 Cleaved Into - Adp/Atp Translocase 3 - N-Terminally Processed antibodyAnti-SLC25A6 antibodyAnti-AAC3 antibodyAnti-ANT3 antibodyAnti-CDABP0051 antibody |
Information sourced from Uniprot.org