| Function | Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. |
| Protein Name | Solute Carrier Family 25 Member 47Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier ProteinMitochondrial Nad(+ Transporter Slc25a47 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 25 Member 47 antibodyAnti-Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein antibodyAnti-Mitochondrial Nad(+ Transporter Slc25a47 antibodyAnti-SLC25A47 antibodyAnti-C14orf68 antibodyAnti-HDMCP antibodyAnti-HMFN1655 antibody |
Information sourced from Uniprot.org
