| Function | Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation. |
| Protein Name | Solute Carrier Family 25 Member 33Bone Marrow Stromal Cell Mitochondrial Carrier ProteinBmsc-McpHubmsc-McpProtein Pnc1 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 25 Member 33 antibodyAnti-Bone Marrow Stromal Cell Mitochondrial Carrier Protein antibodyAnti-Bmsc-Mcp antibodyAnti-Hubmsc-Mcp antibodyAnti-Protein Pnc1 antibodyAnti-SLC25A33 antibody |
Information sourced from Uniprot.org
