| Tissue Specificity | Expressed in placenta, gall bladder and colon. |
| Function | Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable). |
| Protein Name | Mitochondrial 2-Oxodicarboxylate CarrierOdcMitochondrial 2-Oxoadipate CarrierSolute Carrier Family 25 Member 21 |
| Database Links | Reactome: R-HSA-71064 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial 2-Oxodicarboxylate Carrier antibodyAnti-Odc antibodyAnti-Mitochondrial 2-Oxoadipate Carrier antibodyAnti-Solute Carrier Family 25 Member 21 antibodyAnti-SLC25A21 antibodyAnti-ODC antibody |
Information sourced from Uniprot.org
