| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mitochondrial 2-Oxoglutarate/Malate Carrier Protein (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC25A11 |
| Gene ID: |
8402 |
| Uniprot ID: |
M2OM_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC25A11 (NP_003553.2). |
| Immunogen Sequence: |
MAATASAGAGGIDGKPRTSP KSVKFLFGGLAGMGATVFVQ PLDLVKNRMQLSGEGAKTRE YKTSFHALTSILKAEGLRGI YTGLSAGLLRQATYTTTRLG |
| Tissue Specificity | Most highly expressed in the heart. |
| Function | Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria. |
| Protein Name | Mitochondrial 2-Oxoglutarate/Malate Carrier ProteinOgcpAlpha-Oxoglutarate CarrierSolute Carrier Family 25 Member 11Slc25a11 |
| Database Links | Reactome: R-HSA-70263 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial 2-Oxoglutarate/Malate Carrier Protein antibodyAnti-Ogcp antibodyAnti-Alpha-Oxoglutarate Carrier antibodyAnti-Solute Carrier Family 25 Member 11 antibodyAnti-Slc25a11 antibodyAnti-SLC25A11 antibodyAnti-SLC20A4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
