Anti-SLC25A1 antibody (1-311) (STJ112285)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC25A1 (1-311) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A1 |
| Gene ID | 6576 |
| Uniprot ID | TXTP_HUMAN |
| Immunogen Region | 1-311 |
| Immunogen Sequence | MPAPRAPRALAAAAPASGKA KLTHPGKAILAGGLAGGIEI CITFPTEYVKTQLQLDERSH PPRYRGIGDCVRQTVRSHGV LGLYRGLSSLLYGSIPKAAV RFGMFEFLSNHMRDAQGRLD STRGLLCGLGAGVAEAVVVV CPMETIKVKFIHDQTSPNPK YRGFFHGVREIVREQGLKGT YQGLTATVLKQGSNQAIRFF VMTSLRNWYRGDNPNKPMNP LITGVFGAIAGAASVFGNT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-311 of human SLC25A1 (NP_005975.1). |
Additional Info
| Post Translational Modifications | Possesses a short cleavable presequence, which, however, is found to be dispensable both for targeting to mitochondria and insertion into the inner membrane. However, the presequence is required to keep SLC25A1 in a soluble state and thus in an import-competent state. Mature SLC25A1 lacking the presequence is prone to aggregation. |
| Function | Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes. |
| Protein Name | Tricarboxylate Transport Protein - MitochondrialCitrate Transport ProteinCtpMitochondrial Citrate CarrierCicSolute Carrier Family 25 Member 1Tricarboxylate Carrier Protein |
| Database Links | Reactome: R-HSA-428643 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tricarboxylate Transport Protein - Mitochondrial antibodyAnti-Citrate Transport Protein antibodyAnti-Ctp antibodyAnti-Mitochondrial Citrate Carrier antibodyAnti-Cic antibodyAnti-Solute Carrier Family 25 Member 1 antibodyAnti-Tricarboxylate Carrier Protein antibodyAnti-SLC25A1 antibodyAnti-SLC20A3 antibody |
Information sourced from Uniprot.org