| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SLC24A1 |
| Gene ID: |
9187 |
| Uniprot ID: |
NCKX1_HUMAN |
| Immunogen Region: |
330-452 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 330-452 of human SLC24A1 (O60721). |
| Immunogen Sequence: |
GSSPAETKAFTAAWSLRNPS PRTSVSAIKTAPAIVWRLAK KPSTAPSTSTTPTVRAKLTM QVHHCVVVKPTPAMLTTPSP SLTTALLPEELSPSPSVLPP SLPDLHPKGEYPPDLFSVEE RRQ |
| Tissue Specificity | Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer. |
| Post Translational Modifications | The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration. |
| Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. |
| Protein Name | Sodium/Potassium/Calcium Exchanger 1Na(+/K(+/Ca(2+-Exchange Protein 1Retinal Rod Na-Ca+K ExchangerSolute Carrier Family 24 Member 1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-425561Reactome: R-HSA-5619077 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Potassium/Calcium Exchanger 1 antibodyAnti-Na(+/K(+/Ca(2+-Exchange Protein 1 antibodyAnti-Retinal Rod Na-Ca+K Exchanger antibodyAnti-Solute Carrier Family 24 Member 1 antibodyAnti-SLC24A1 antibodyAnti-KIAA0702 antibodyAnti-NCKX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
