Anti-SLC24A1 antibody (154-203) (STJ94357)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human SLC24A1. AA range:154-203
General Information
| Short Description | Rabbit polyclonal anti-Sodium/potassium/calcium exchanger 1/K+/Ca2+-exchange protein 1 (154-203) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC24A1 |
| Gene ID | 9187 |
| Uniprot ID | NCKX1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SLC24A1. AA range:154-203 |
| Immunogen Region | 154-203 |
| Specificity | NCKX1 Polyclonal Antibody detects endogenous levels of NCKX1 protein. |
Additional Info
| Tissue Specificity | Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer. |
| Post Translational Modifications | The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration. |
| Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. |
| Protein Name | Sodium/Potassium/Calcium Exchanger 1Na(+/K(+/Ca(2+-Exchange Protein 1Retinal Rod Na-Ca+K ExchangerSolute Carrier Family 24 Member 1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-425561Reactome: R-HSA-5619077 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Potassium/Calcium Exchanger 1 antibodyAnti-Na(+/K(+/Ca(2+-Exchange Protein 1 antibodyAnti-Retinal Rod Na-Ca+K Exchanger antibodyAnti-Solute Carrier Family 24 Member 1 antibodyAnti-SLC24A1 antibodyAnti-KIAA0702 antibodyAnti-NCKX1 antibody |
Information sourced from Uniprot.org