| Function | Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations. Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine. Transports one sodium ion with one ergothioeine molecule. Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body. Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet. Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system. Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports. May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier. |
| Protein Name | Solute Carrier Family 22 Member 4Ergothioneine TransporterEt TransporterEtthOrganic Cation/Carnitine Transporter 1Octn1 |
| Database Links | Reactome: R-HSA-549127 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneMitochondrion MembraneLocalized To The Apical Membrane Of Small IntestinesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 4 antibodyAnti-Ergothioneine Transporter antibodyAnti-Et Transporter antibodyAnti-Etth antibodyAnti-Organic Cation/Carnitine Transporter 1 antibodyAnti-Octn1 antibodyAnti-SLC22A4 antibodyAnti-ETT antibodyAnti-OCTN1 antibodyAnti-UT2H antibody |
Information sourced from Uniprot.org
