| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Solute carrier family 22 member 4 (240-320 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC22A4 |
| Gene ID: | 6583 |
| Uniprot ID: | S22A4_HUMAN |
| Immunogen Region: | 240-320 aa |
| Specificity: | S22A4 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 240-320 |
| Function | Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations. Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine. Transports one sodium ion with one ergothioeine molecule. Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body. Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet. Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system. Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports. May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier. |
| Protein Name | Solute Carrier Family 22 Member 4 Ergothioneine Transporter Et Transporter Etth Organic Cation/Carnitine Transporter 1 Octn1 |
| Database Links | Reactome: R-HSA-549127 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Basal Cell Membrane Mitochondrion Membrane Localized To The Apical Membrane Of Small Intestines Localized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 4 antibody Anti-Ergothioneine Transporter antibody Anti-Et Transporter antibody Anti-Etth antibody Anti-Organic Cation/Carnitine Transporter 1 antibody Anti-Octn1 antibody Anti-SLC22A4 antibody Anti-ETT antibody Anti-OCTN1 antibody Anti-UT2H antibody |
Information sourced from Uniprot.org