| Tissue Specificity | Ubiquitously expressed. |
| Function | Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization. Required to maintain normal cerebrospinal fluid phosphate levels. Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs. (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. |
| Protein Name | Sodium-Dependent Phosphate Transporter 2Gibbon Ape Leukemia Virus Receptor 2Glvr-2Phosphate Transporter 2Pit-2Pit2Hpit2Solute Carrier Family 20 Member 2 |
| Database Links | Reactome: R-HSA-427652Reactome: R-HSA-5619111 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Antibody Names | Anti-Sodium-Dependent Phosphate Transporter 2 antibodyAnti-Gibbon Ape Leukemia Virus Receptor 2 antibodyAnti-Glvr-2 antibodyAnti-Phosphate Transporter 2 antibodyAnti-Pit-2 antibodyAnti-Pit2 antibodyAnti-Hpit2 antibodyAnti-Solute Carrier Family 20 Member 2 antibodyAnti-SLC20A2 antibodyAnti-GLVR2 antibodyAnti-PIT2 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and TTLL12 knockout (KO) 293T cells, using [KO Validated] TTLL12 Rabbit polyclonal antibody (STJ11100870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/89804/358271/STJ11100870_1__29815.1713122614.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TTLL12 knockout (KO) 293T cells, using [KO Validated] TTLL12 Rabbit polyclonal antibody (STJ11100870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
