| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC1A7 (480-560) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC1A7 |
| Gene ID: |
6512 |
| Uniprot ID: |
EAA5_HUMAN |
| Immunogen Region: |
480-560 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 480-560 of human SLC1A7 (NP_006662.3). |
| Immunogen Sequence: |
DFARDTGTEKLLPCETKPVS LQEIVAAQQNGCVKSVAEAS ELTLGPTCPHHVPVQVEQDE ELPAASLNHCTIQISELETN V |
| Tissue Specificity | Expressed primarily in retina. Detectable in liver, heart, muscle and brain. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina. |
| Protein Name | Excitatory Amino Acid Transporter 5Retinal Glutamate TransporterSolute Carrier Family 1 Member 7 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393 |
| Cellular Localisation | Photoreceptor Inner Segment MembraneMulti-Pass Membrane ProteinSynaptic Cell MembraneLocated In Both Cone And Rod Photoreceptor Terminals And In Axon Terminals Of Rod Bipolar Cells |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 5 antibodyAnti-Retinal Glutamate Transporter antibodyAnti-Solute Carrier Family 1 Member 7 antibodyAnti-SLC1A7 antibodyAnti-EAAT5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
