| Tissue Specificity | Expressed primarily in retina. Detectable in liver, heart, muscle and brain. |
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina. |
| Protein Name | Excitatory Amino Acid Transporter 5Retinal Glutamate TransporterSolute Carrier Family 1 Member 7 |
| Database Links | Reactome: R-HSA-210500Reactome: R-HSA-425393 |
| Cellular Localisation | Photoreceptor Inner Segment MembraneMulti-Pass Membrane ProteinSynaptic Cell MembraneLocated In Both Cone And Rod Photoreceptor Terminals And In Axon Terminals Of Rod Bipolar Cells |
| Alternative Antibody Names | Anti-Excitatory Amino Acid Transporter 5 antibodyAnti-Retinal Glutamate Transporter antibodyAnti-Solute Carrier Family 1 Member 7 antibodyAnti-SLC1A7 antibodyAnti-EAAT5 antibody |
Information sourced from Uniprot.org
